The molecular genetic makeup of acute lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizi...
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From its beginnings two decades ago with the analysis of chromosomal translocation breakpoints, research into the molecular pathogenesis of acute lymphoblastic leukemia (ALL) has now progressed to the large-scale resequencing of candidate oncogenes and tumor suppressor genes in the genomes of ALL cases blocked at various developmental stages within the B- and T-cell lineages. In this review, we...
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This concise review focuses on the most recent advances in understanding molecular genetic abnormalities in childhood acute leukemia (ALL). An increasing number of chromosomal translocations associated to distinct molecular genetic abnormalities have been described. Recurrent motifs have been recognized behind the great heterogeneity of genes involved in chromosomal translocations occurring in ...
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Acute lymphoblastic leukemia (ALL) occurs with high frequency in childhood and is associated with high mortality in adults. Recent technical advances in next-generation sequencing have shed light on genetic abnormalities in hematopoietic stem/progenitor cells as the precursor to ALL pathogenesis. Based on these genetic abnormalities, ALL is now being reclassified into newly identified subtypes....
متن کاملReview Series ACUTE LYMPHOBLASTIC LEUKEMIA Inherited genetic variation in childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common cancer in children, accounting for 25%of all childhoodmalignancies. Sentinel chromosomal abnormalities (translocations or aneuploidy) are characteristic of the majority of ALL cases, and recent genomic profiling of leukemic cells continues to broaden our appreciation of the complex genomic landscape of this disease. These somatically acquire...
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ژورنال
عنوان ژورنال: Hematology
سال: 2012
ISSN: 1520-4391,1520-4383
DOI: 10.1182/asheducation.v2012.1.389.3798360